Wang, Bingbing; Peng, Pan; Ma, Wan; Liu, Zhao; Huang, Cheng; Cao, Yangmin; Hu, Ping; Qi, Xiaotian; Lu, Qingquan published the artcile< Electrochemical Borylation of Alkyl Halides: Fast, Scalable Access to Alkyl Boronic Esters>, Synthetic Route of 16799-05-6, the main research area is electrochem borylation alkyl halide reduction mechanism DFT; alkyl boronic ester preparation electrochem; mol structure optimized boronic ester alkyl halide DFT.
Herein, a fast, scalable, and transition-metal-free borylation of alkyl halides (X = I, Br, Cl) enabled by electroreduction is reported. This process provides an efficient and practical access to primary, secondary, and tertiary boronic esters at a high current. More than 70 examples, including the late-stage borylation of natural products and drug derivatives, are furnished at room temperature, thereby demonstrating the broad utility and functional-group tolerance of this protocol. Mechanistic studies disclosed that B2cat2 serves as both a reagent and a cathodic mediator, enabling electroreduction of difficult-to-reduce alkyl bromides or chlorides at a low potential.
Journal of the American Chemical Society published new progress about Bond cleavage. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Synthetic Route of 16799-05-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics