Xiang, Ming; Zhou, Chao; Yang, Xiu-Long; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu published the artcile< Visible Light-Catalyzed Benzylic C-H Bond Chlorination by a Combination of Organic Dye (Acr+-Mes) and N-Chlorosuccinimide>, Product Details of C4H4ClNO2, the main research area is alkylbenzene chlorination light photocatalyst chlorosuccinimide oxidative quenching; benzylic chloride preparation; one pot benzylic ether preparation.
By combining “”N-chlorosuccinimide (NCS)”” as the safe chlorine source with “”Acr+-Mes”” as the photocatalyst, we successfully achieved benzylic C-H bond chlorination under visible light irradiation Furthermore, benzylic chlorides could be converted to benzylic ethers smoothly in a one-pot manner by adding sodium methoxide. This mild and scalable chlorination method worked effectively for diverse toluene derivatives, especially for electron-deficient substrates. Careful mechanistic studies supported that NCS provided a hydrogen abstractor “”N-centered succinimidyl radical,”” which was responsible for the cleavage of the benzylic C-H bond, relying on the reducing ability of Acr•-Mes.
Journal of Organic Chemistry published new progress about Alkylbenzenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Product Details of C4H4ClNO2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics