Zhang, Hong; Di, Shu-Sheng; Huang, Xiao-Bo; Zhou, Yun-Bing; Liu, Miao-Chang; Wu, Hua-Yue published the artcile< Direct dilithiation of N-aryl heterocycles for the construction of condensed N-heterocycles>, Electric Literature of 17082-09-6, the main research area is condensed heterocycle preparation; aryl heterocycle direct dilithiation acyl chloride trapping.
A 1,4-dilithio intermediate can be prepared from N-heterocycles by n-BuLi-promoted direct C-H dilithiation. The subsequent trapping of the 1,4-dilithio intermediate with acyl chlorides affords condensed N-heterocycles in high yields in a one-pot fashion. This protocol features a broad substrate scope, good efficiency, and high atom economy. The control experiments support the presence of a 1,4-dilithio intermediate.
Organic Chemistry Frontiers published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Electric Literature of 17082-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics