Akgul, Ozlem; Angeli, Andrea; Selleri, Silvia; Capasso, Clemente; Supuran, Claudiu T.; Carta, Fabrizio published an article in European Journal of Medicinal Chemistry. The title of the article was 《Taurultams incorporating arylsulfonamide: First in vitro inhibition studies of α-, β- and γ-class Carbonic Anhydrases from Vibrio cholerae and Burkholderia pseudomallei》.COA of Formula: C7H6Cl2 The author mentioned the following in the article:
A new series of taurultambenzenesulfonamides I and II were prepared and considered for their inhibitory activity in vitro against the Carbonic Anhydrases from Vibrio cholerae (VchCA-α, VchCA-β and VchCA-γ) and Burkholderia pseudomallei (BpsCA-β and BpsCA-γ). Among the compounds tested, derivatives I (R = 4-CF3, 4-NO2, F5) and II (R = H, 4-F, 2,6-F2) resulted in highly effective VchCAα inhibitors (KI values spanning within the 6.1-9.6 nM range) and endowed with excellent Selectivity Indexes (SIs; KI VchCA-α/KI hCA II) all comprised between 0.04 and 0.09. Potent in vitro inhibitors for the BpsCA-γ were also identified (KIs of 18.9-19.5 nM). The results here reported may represent the blueprint for the future development of a new generation of CA-based antibiotics integrated with free of resistance mechanisms of action adopted from known drugs. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2COA of Formula: C7H6Cl2)
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.COA of Formula: C7H6Cl2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics