Al-Masum, Mohammad; Legan, Sarah; Liu, Kwei-Yu published the artcile< Pd-catalyzed microwave irradiated regioselective aroylation reaction of crotyl- and allyltrifluoroborates>, Quality Control of 162046-61-9, the main research area is alkenone preparation regioselective diastereoselective chemoselective microwave irradiation; trifluoroborate salt aroyl chloride aroylation palladium catalyst.
An interesting regioselectivity is observed when the mixture of potassium crotyltrifluoroborate and aroyl chlorides RC(O)Cl (R = 3,4,6-trifluorophenyl, naphth-2-yl, 4-bromophenyl, etc.) having electron-deficient and electron-rich groups is microwaved in the presence of palladium-catalyst. In the case of electron withdrawing group with Ph ring of aroyl chlorides, isomerized α,β-unsaturated compound RC(O)CH(CH3)=CHCH3 is a product, whereas the electron donating group with Ph ring of aroyl chlorides furnishes α-adduct RC(O)CH(CH3)CH=CH2. Similar aroylation reaction is also established for potassium allyltrifluoroborate. In this case, regioselectivity is unaffected with changing electron-rich or electron-deficient groups in Ph ring of the aroyl chlorides. Reactions proceed with, essentially in same rate, to afford the corresponding aryl propenyl ketones (crotonophenones) RC(O)CH=CHCH3 in good to high yields.
International Journal of Organic Chemistry published new progress about Aromatic acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Quality Control of 162046-61-9.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics