In 2022,Bendelac, Audrey; Benedetti, Francoise; Doublet-Decabras, Valerie; Lokovi, Rachel; Decalogne, Francois; Bigot, Antony published an article in Organic Process Research & Development. The title of the article was 《Fit-for-Purpose Synthesis of an Aza-Cryptophycin Analogue as the Payload for an Antibody-Drug Conjugate》.Computed Properties of C43H72Cl2P2Ru The author mentioned the following in the article:
The synthesis of an aza-cryptophycin analog (I) is described, featuring a highly trans-selective ring-closing metathesis reaction and an asym. Corey-Chaykovsky-type reaction to install the epoxide function. This latter reaction is an answer to the long-standing synthetic challenged posed by the efficient formation of the epoxide function of the cryptophycin family of compounds in a diastereoselective manner. It allows for a one-third reduction in the number of steps compared with the previously used synthesis (27 to 19 steps) and increases the overall yield of the longest linear sequence by a factor of 27 (0.6% to 16%). This fit-for-purpose synthesis allowed the production of a steady supply of the material for the early phase of a cryptophycin-based antibody-drug conjugate program. Safety: cryptophycin analogs are highly cytotoxic and should be prepared with appropriate precautions, and decomposition risk of chiral sulfonium. In the part of experimental materials, we found many familiar compounds, such as Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Computed Properties of C43H72Cl2P2Ru)
Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Computed Properties of C43H72Cl2P2Ru
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics