In 2019,European Journal of Organic Chemistry included an article by Cheng, Xinqiang; Shan, Jiankai; Tian, Xinshe; Ren, Yun-Lai; Zhu, Yanyan. Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Benzylation of Arenes with Benzyl Halides under Promoter-Free and Additive-Free Conditions》. The information in the text is summarized as follows:
It was found that benzyl chlorides and bromides could directly reacted with electron-rich arenes which provided an example of promoter-free and additive-free benzylation of arenes. A variety of benzyl chlorides and bromides were treated with benzene rings to give the targeted products in low to high yields. The present conditions tolerated the vinyl group of the substrates. Preliminary mechanistic investigation suggested that the present reactions possibly proceeded via an autocatalytic mechanism pathway. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics