In 2022,ARKIVOC (Gainesville, FL, United States) included an article by De Luca, Laura; Mirabile, Salvatore; Ricci, Federico; Adornato, Ilenia; Cacciola, Anna; Germano, Maria Paola; Gitto, Rosaria. Reference of 3-Chlorobenzylchloride. The article was titled 《Synthesis and biochemical evaluation of 5-(pyridin-4-yl)-3-(alkylsulfanyl)-4H-1,2,4-triazol-4-amine-based inhibitors of tyrosinase from Agaricus bisporus》. The information in the text is summarized as follows:
A series of small mols. able to inhibit diphenolase activity of tyrosinase from Agaricus bisporus. The designed compounds I [n = 1,2; R = H, 4-Me, 2,4-F etc.] were readily synthesized by S-alkylation and the synthesized compounds I were tested through biochem. screening, thus provided structure-affinity relationships for this class of comp. I . In addition, docking simulations suggested the binding mode within the catalytic site of the targeted enzyme.3-Chlorobenzylchloride(cas: 620-20-2Reference of 3-Chlorobenzylchloride) was used in this study.
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Reference of 3-Chlorobenzylchloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics