Du, Xiaochen; Yu, Jiafeng; Gong, Jing; Zaman, Manzoor; Pereshivko, Olga P.; Peshkov, Vsevolod A. published the artcile< Gold-Catalyzed Post-Ugi Cascade Transformation for the Synthesis of 2-Pyridones>, Electric Literature of 3240-10-6, the main research area is propiolic acid isocyanide aldehyde aniline Ugi one pot; bisamide preparation; furan alkyne cyclization ring opening cleavage gold catalyst diastereoselective; pyridone stereoselective cascade preparation.
A gold-catalyzed post-Ugi cascade transformation for the synthesis of 2-pyridones is described. The process involves furan-alkyne cyclization followed by furan ring-opening and cleavage of the isocyanide-originated fragment. The initially formed cis double bond can isomerize into a more stable trans double bond, e.g. I, upon prolonged exposure to a strong Bronsted acid. Thus, the overall strategy provides a viable access towards two types of 2-pyridones.
European Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Electric Literature of 3240-10-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics