《Discovery of novel tertiary amide derivatives as NEDDylation pathway activators to inhibit the tumor progression in vitro and in vivo》 was written by Fu, Dong-Jun; Song, Jian; Zhu, Ting; Pang, Xiao-Jing; Wang, Sheng-Hui; Zhang, Yan-Bing; Wu, Bo-Wen; Wang, Jun-Wei; Zi, Xiaolin; Zhang, Sai-Yang; Liu, Hong-Min. Related Products of 620-20-2 And the article was included in European Journal of Medicinal Chemistry on April 15 ,2020. The article conveys some information:
NEDDylation pathway regulates multiple physiol. process, unlike inhibitors, NEDDylation activators are rarely studied. Novel amide derivatives were synthesized and evaluated for antiproliferative activity against MGC803, MCF-7 and PC-3 cells. Among them, VII-31 displayed the most potent activity with an IC50 value of 94 nmol/L against MGC803 cells. Cellular mechanisms elucidated that VII-31 inhibited the cell viability, arrested cell cycle at G2/M phase and induced apoptosis via intrinsic and extrinsic pathways against MGC803 cells. In addition, VII-31 activated NAE1-Ubc12-Cullin1 NEDDylation via interacting with NAE1 directly. Furthermore, the activation of NEDDylation resulted in the degradation of inhibitor of apoptosis proteins (IAPs). Importantly, VII-31 inhibited tumor growth in xenograft models in vivo without the apparent toxicity. In summary, it is the first time to reveal that VII-31 deserves consideration for cancer therapy as a NEDDylation activator.3-Chlorobenzylchloride(cas: 620-20-2Related Products of 620-20-2) was used in this study.
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Related Products of 620-20-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics