Hu, Xu-Dong; Chen, Zi-Hao; Zhao, Jing; Sun, Rui-Ze; Zhang, Hui; Qi, Xiaotian; Liu, Wen-Bo published their research in Journal of the American Chemical Society in 2021. The article was titled 《Enantioselective Synthesis of α-All-Carbon Quaternary Center-Containing Carbazolones via Amino-Palladation/Desymmetrizing Nitrile Addition Cascade》.Quality Control of Methyl 2-chloro-2-oxoacetate The article contains the following contents:
An enantioselective Pd(II)-catalyzed amino-cyclization and desymmetrizing nitrile addition cascade reaction of alkyne-tethered malononitriles is reported. This reaction forms two rings and one quaternary carbon center in a single step and serves as a novel strategy for the construction of α-quaternary carbazolones with high enantioselectivities (up to 98:2 er). The utility of this method is demonstrated by product derivatization into a diverse array of heterocycles and a nitrile-containing leucomidine A analog. In the part of experimental materials, we found many familiar compounds, such as Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Quality Control of Methyl 2-chloro-2-oxoacetate)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Quality Control of Methyl 2-chloro-2-oxoacetate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics