Ishikawa, Hiroki; Ban, Kazuma; Uemura, Naohiro; Yoshida, Yasushi; Mino, Takashi; Kasashima, Yoshio; Sakamoto, Masami published an article on February 24 ,2020. The article was titled 《Attrition-Enhanced Deracemization of Axially Chiral Nicotinamides》, and you may find the article in European Journal of Organic Chemistry.Synthetic Route of C8H8ClNO2 The information in the text is summarized as follows:
Attrition-enhanced deracemization of two axially chiral nicotinamides, crystallizing as a conglomerate of a P21 crystal system, was performed. N,N-Dialkylnicotinamides with substituents on the 2- and 4-positions of the pyridine ring exhibited stable axial chirality due to rotationally restricted scaffolds for the Ar-C(=O)N bond. Crystallization of the racemic mixtures from the melt or attrition-enhanced deracemization led to the chiral breaking of symmetry to give 95-96% ee of enantiomorphic crystals. In the experiment, the researchers used many compounds, for example, 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Synthetic Route of C8H8ClNO2)
2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Synthetic Route of C8H8ClNO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics