《Hybrid Palladium Catalyst Assembled from Chiral Phosphoric Acid and Thioamide for Enantioselective β-C(sp3)-H Arylation》 was written by Jiang, Hua-Jie; Zhong, Xiu-Mei; Liu, Zi-Ye; Geng, Rui-Long; Li, Yang-Yang; Wu, Yun-Dong; Zhang, Xinhao; Gong, Liu-Zhu. SDS of cas: 768-35-4 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:
A hybrid palladium catalyst assembled from a chiral phosphoric acid (CPA) and thioamide enables a highly efficient and enantioselective β-C(sp3)-H functionalization of thioamides (up to 99% yield, 97% ee; e.g., N,N-diisopropyl isobutyric thioamide + PhB(OH)2 → I (91% isolated, 96% ee)). A kinetic resolution of unsym. thioamides by intermol. C(sp3)-H arylation can be achieved with high s-factors. Mechanistic investigations have revealed that stereocontrol is achieved by embedding the substrate in a robust chiral cavity defined by the bulky CPA and a neutral thioamide ligand. After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4SDS of cas: 768-35-4)
(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.SDS of cas: 768-35-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics