Judge, Neil R.; Chacktas, Geraud; Ma, Ling; Schink, Anke; Buckpesch, Rainer; Schmutzler, Dirk; Machettira, Anu B.; Dietrich, Hansjorg; Asmus, Elisabeth; Bierer, Donald; McLeod, Michael C. published an article in 2021. The article was titled 《Flexible Synthesis and Herbicidal Activity of Fully Substituted 3-Hydroxypyrazoles》, and you may find the article in European Journal of Organic Chemistry.Recommanded Product: 622-95-7 The information in the text is summarized as follows:
The synthesis and herbicidal efficacy of a novel library of fully substituted 3-hydroxypyrazoles I (R1 = H, Me, Et, i-Pr, 2-methoxyethyl; R2 = H, 2,4-F2, 3,4-F2, 3-Cl, etc.; A = O, S, CH2, etc.) is reported. An efficient, divergent approach to introduce Ph, phenoxy, phenylsulfanyl, anilino and benzyl substituents in the 4-position of the pyrazole, alongside a flexible synthesis of N1-alkyl analogs I is described via final step diversification of key intermediates. Herbicidal screening of the prepared compounds against key weed species identified the lead compound I (R1 = Me; R2 = H, 2,4-F2; A = O), which was prepared on a multi-gram scale using an optimized synthetic route. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 622-95-7)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Recommanded Product: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics