Kamala, L.; Kumar, B. Sathish; Lakshmi, P. V. Anantha published their research in Russian Journal of Bioorganic Chemistry in 2021. The article was titled 《Synthesis and Docking Studies of Novel Carbazole-Thiazolidinedione Hybrid Derivatives as Antibacterial Agents》.Name: 1-(Bromomethyl)-4-chlorobenzene The article contains the following contents:
A series of novel carbazole-thiazolidinedione hybrids I (R = Ph, 4-O2NC6H4, 2,4-Cl2C6H3, etc.) was designed, synthesized and screened for antimicrobial activity against Gram-pos. and Gram-neg. bacterial species. All the novel compounds were characterized by 1H, 13C NMR, IR and mass spectral anal. data. The results of antibacterial study indicated that compounds I (R = 2-O2NC6H4, 2-BrC6H4) showed appreciable antibacterial activity. Furthermore, mol. docking of selected compounds was performed to study the interaction between active compound and binding site. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics