Formula: C8H6Cl2O3On June 11, 2015, Keurulainen, Leena; Vahermo, Mikko; Puente-Felipe, Margarita; Sandoval-Izquierdo, Elena; Crespo-Fernandez, Benigno; Guijarro-Lopez, Laura; Huertas-Valentin, Leticia; de las Heras-Duena, Laura; Leino, Teppo O.; Siiskonen, Antti; Ballell-Pages, Lluis; Sanz, Laura M.; Castaneda-Casado, Pablo; Jimenez-Diaz, M. Belen; Martinez-Martinez, Maria S.; Viera, Sara; Kiuru, Paula; Calderon, Felix; Yli-Kauhaluoma, Jari published an article in Journal of Medicinal Chemistry. The article was 《A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides》. The article mentions the following:
Malaria continues to be a major global health problem, being particularly devastating in the African population under the age of five. Artemisinin-based combination therapies (ACTs) are the first-line treatment recommended by the WHO to treat Plasmodium falciparum malaria, but clin. resistance against them has already been reported. As a consequence, novel chemotypes are urgently needed. Herein the authors report a novel, in vivo active, fast-acting antimalarial chemotype based on a benzimidazole core. This discovery is the result of a medicinal chem. plan focused on improving the developability profile of an antichlamydial chem. class previously reported by the group. In the experiment, the researchers used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Formula: C8H6Cl2O3)
3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Formula: C8H6Cl2O3 The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics