Kovalcik, Thomas R.; Guillory, J. Keith published the artcile< Stability of cyclophosphamide in lyophilized cakes. II. Urea, polyvinylpyrrolidone, and dextran as excipients>, COA of Formula: C7H17Cl2N2O3P, the main research area is cyclophosphamide stability lyophilization; excipient cyclophosphamide stability lyophilization.
Lyophilized products containing cyclophosphamide (I) and one of the following excipients: urea, polyvinylpyrrolidone (PVP-40), or dextran, were prepared All of the products were well-formed cakes. I in these lyophilized cakes underwent rapid (t90 < 30 days) degradation in the solid state at room temperature The lyophilized cakes were humidified with 5 μL water. In the cake containing urea, DSC and x-ray diffraction showed that I was converted from the amorphous to the monohydrate form when exposed to moisture, and exhibited improved stability. In the case of the cake containing PVP-40, the incorporation of moisture resulted in formation of a clear, semi-solid possessing poor stability. The I/dextran cake remained intact upon humidification. DSC and x-ray diffraction showed that I in this cake was not converted from the amorphous form to the monohydrate form, and exhibited no improvement in stability. Journal of Parenteral Science and Technology published new progress about Freeze drying. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, COA of Formula: C7H17Cl2N2O3P.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics