Lin, Lin; Lin, Guangyao; Zhou, Qingtong; Bathgate, Ross A. D.; Gong, Grace Qun; Yang, Dehua; Liu, Qing; Wang, Ming-Wei published the artcile< Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists>, HPLC of Formula: 2905-54-6, the main research area is tricyclic fused azolopyrimidine preparation RXFP4 agonist SAR docking; Molecular docking; Relaxin family peptide receptor 4; Selective agonist; Structure-activity relationship; Synthesis.
A new scaffold of tricyclic derivatives I [X = CH2, O, S, Me2C; Y = CH2, Me2C; V = CH, N, (2-ClC6H4)C, etc.; W = CH, N; R = OH, SH, MeS, pyrrolidin-1-yl] represented by compound I [X = Y = CH2, V = (2-ClC6H4)C, W = N, R = OH] was disclosed as a selective RXFP4 agonist after a high-throughput screening campaign against a diverse library of 52,000 synthetic and natural compounds Two rounds of structural modification around this scaffold were performed focusing on three parts: 2-chlorophenyl group, 4-hydroxylphenyl group and its skeleton including cyclohexane-1,3-dione and 1,2,4-triazole group. Compound I [X = S, Y = CH2, V = (2-IC6H4)C, W = N, R = OH] with a new skeleton of was thus obtained. The enantiomers of compounds I [X = Y = CH2, V = (2-ClC6H4)C, W = N, R = OH] and I [X = S, Y = CH2, V = (2-IC6H4)C, W = N, R = OH] were also resolved with their 9-(S)-conformer favoring RXFP4 agonism. Compared with compound I [X = Y = CH2, V = (2-ClC6H4)C, W = N, R = OH], compound 9-(S)-[X = S, Y = CH2, V = (2-IC6H4)C, W = N, R = OH] exhibited 2.3-fold higher efficacy and better selectivity for RXFP4 (selective ratio of RXFP4 vs. RXFP3 for 9-(S)-[X = S, Y = CH2, V = (2-IC6H4)C, W = N, R = OH] and I [X = Y = CH2, V = (2-ClC6H4)C, W = N, R = OH] were 26.9 and 13.9, resp.).
Bioorganic Chemistry published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, HPLC of Formula: 2905-54-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics