Liu, Hongyan; Sun, Danwen; Du, Hang; Zheng, Changji; Li, Jingya; Piao, Huri; Li, Jia; Sun, Liangpeng published an article in European Journal of Medicinal Chemistry. The title of the article was 《Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents》.Recommanded Product: 620-20-2 The author mentioned the following in the article:
Several series of novel tryptophan-derived rhodanine derivatives were synthesized and identified as potential competitive PTP1B inhibitors and antibacterial agents. Among the compounds studied, I [R = 4-Br] was found to have the best in vitro inhibition activity against PTP1B (IC50 = 0.36 ± 0.02 μM). In addition, the compounds also showed potent inhibition against other PTPs, especially CDC25B. Mol. docking anal. demonstrated that compounds II and I [R = 4-Br] could occupy both the catalytic site and the adjacent pTyr binding site simultaneously. The compounds also showed higher levels of activity against gram-pos. strains, the gram-neg. strain Escherichia coli 1924, and multidrug-resistant gram-pos. bacterial strains. Compounds II, III, IV and I [R = 4-Me, 4-F] had comparable or more potent antibacterial activity than the pos. controls. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 620-20-2)
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 620-20-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics