Liu, Runlai; Huang, Mingxin; Zhang, Shuai; Li, Long; Li, Mi; Sun, Jun; Wu, Lan; Guan, Qi; Zhang, Weige published an article in 2021. The article was titled 《Design, synthesis and bioevaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles as tubulin polymerization inhibitors》, and you may find the article in European Journal of Medicinal Chemistry.Quality Control of (3-Fluorophenyl)boronic acid The information in the text is summarized as follows:
A series of new 6- substututed phenyl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles I [R = H, 4-F, 2-F-4-Me, etc.] as tubulin polymerization inhibitors targeting the colchicine-binding site were designed to restrict bioactive configuration of (Z,E)-vinylogous CA-4. All of the target compounds I were synthesized and then evaluated for their in-vitro antiproliferative activities. Among them, compound I [R = 3-HO-4-MeO] exhibited the most potent activities against three cancer cell lines with IC50 values in the range of 0.037-0.20μM. Further mechanism studies revealed that compound I [R = 3-HO-4-MeO] inhibited tubulin polymerization, disrupted cell microtubule networks, arrested the cell cycle at G2/M phase, induced apoptosis and hindered cancer cell migration. Moreover, compound I [R = 3-HO-4-MeO] displayed significant in-vivo antitumor efficacy in 4T1-xenograft mice model with tumor growth inhibition rate of 52% at the dose of 2.5 mg/kg. Colchicine competition assay and the docking model of compound I [R = 3-HO-4-MeO] in complex with tubulin showed that compound I [R = 3-HO-4-MeO] acted at the colchicine-binding site. After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4Quality Control of (3-Fluorophenyl)boronic acid)
(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Quality Control of (3-Fluorophenyl)boronic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics