Ma, Wei-Yuan; Han, Guan-Yu; Kang, Shaolin; Pang, Xiaobo; Liu, Xue-Yuan; Shu, Xing-Zhong published their research in Journal of the American Chemical Society in 2021. The article was titled 《Cobalt-Catalyzed Enantiospecific Dynamic Kinetic Cross-Electrophile Vinylation of Allylic Alcohols with Vinyl Triflates》.Application of 5781-53-3 The article contains the following contents:
A cobalt-catalyzed enantiospecific vinylation reaction of allylic alcs. with vinyl triflates is reported. This work establishes a new method for synthesis of enantioenriched 1,4-dienes, e.g., I. The reaction proceeds through a dynamic kinetic coupling approach, which not only allows for direct functionalization of allylic alcs. but also is essential to achieve high chemoselectivity. The use of cobalt enables reactions to proceed with high enantiospecificity, which have failed to be realized by nickel catalysts. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 5781-53-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics