In 1984,Journal of Medicinal Chemistry included an article by Meindl, Wolfgang R.; Von Angerer, Erwin; Schoenenberger, Helmut; Ruckdeschel, Gotthard. Formula: C8H10Cl3N. The article was titled 《Benzylamines: synthesis and evaluation of antimycobacterial properties》. The information in the text is summarized as follows:
The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra were described. The most active compounds: I.HCl (MIC 10.2 μg/mL), II. HCl (MIC 10.2 μg/mL), and III.HCl (MIC 6.4 μg/mL), also had a marked inhibitory effect on M. marinum and M. lufu. The combination of II with aminosalicylic acid, streptomycin, or dapsone had marked supra-additive effects on M. tuberculosis H 37 Ra. In the experiment, the researchers used many compounds, for example, 1-(2,6-Dichlorophenyl)-N-methylmethanamine hydrochloride(cas: 90389-15-4Formula: C8H10Cl3N)
1-(2,6-Dichlorophenyl)-N-methylmethanamine hydrochloride(cas: 90389-15-4) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Formula: C8H10Cl3N
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics