Muthu Ramalingam, Bose; Dhatchana Moorthy, Nachiappan; Chowdhury, Somenath Roy; Mageshwaran, Thiyagarajan; Vellaichamy, Elangovan; Saha, Sourav; Ganesan, Karthikeyan; Rajesh, B. Navin; Iqbal, Saleem; Majumder, Hemanta K.; Gunasekaran, Krishnasamy; Siva, Ramamoorthy; Mohanakrishnan, Arasambattu K. published an article on February 8 ,2018. The article was titled 《Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues》, and you may find the article in Journal of Medicinal Chemistry.Safety of 3,5-Dichloro-2-nitrobenzaldehyde The information in the text is summarized as follows:
A series of calothrixin B analogs bearing substituents at the ‘E’ ring and their corresponding deoxygenated quinocarbazoles lacking quinone unit were synthesized. The cytotoxicities of calothrixins and quinocarbazole analogs were investigated against nine cancer cell lines. Two quinocarbazoles inhibited the catalytic activity of human topoisomerase II. The plasmid DNA cleavage abilities of calothrixins identified compound I causing DNA cleavage comparable to that of calothrixin A. Calothrixin A, 3-fluorocalothrixin I and 4-fluoroquinocarbazole II induced extensive DNA damage followed by apoptotic cell death. Spectral and plasmid unwinding studies demonstrated an intercalative mode of binding for quinocarbazoles. We identified two promising drug candidates, the 3-fluorocalothrixin B I with low toxicity in animal model and its deoxygenated derivative 4-fluoroquinocarbazole II as having potent cytotoxicity against NCI-H460 cell line with a GI50 of 1 nM. In the experiment, the researchers used 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Safety of 3,5-Dichloro-2-nitrobenzaldehyde)
3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Safety of 3,5-Dichloro-2-nitrobenzaldehyde The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics