《Stereoselective [4+2]-Cycloaddition with Chiral Alkenylboranes》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Ni, Dongshun; Witherspoon, Brittany P.; Zhang, Hong; Zhou, Chen; Houk, K. N.; Brown, M. Kevin. Product Details of 5781-53-3 The article mentions the following:
A method for the stereoselective [4+2]-cycloaddition of alkenylboranes and dienes is presented. This transformation was accomplished through the introduction of a new strategy that involves the use of chiral N-protonated alkenyl oxazaborolidines as dienophiles. The reaction leads to the formation of products that can be readily derivatized to more complex structural motifs through stereospecific transformations of the C-B bond such as oxidation and homologation. Detailed computation evaluation of the reaction has uncovered a surprising role of the counterion on stereoselectivity. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Product Details of 5781-53-3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Product Details of 5781-53-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics