Sanchez-Velasco, Oriel A.; Saavedra-Olavarria, Jorge; Araya-Santelices, Daniel A. A.; Hermosilla-Ibanez, Patricio; Cassels, Bruce K.; Perez, Edwin G. published their research in Journal of Natural Products in 2021. The article was titled 《Synthesis of N-Arylcytisine Derivatives Using the Copper-Catalyzed Chan-Lam Coupling》.Computed Properties of C6H6BFO2 The article contains the following contents:
N-Arylcytisine derivatives are quite rare. We report here a practical methodol. to obtain these compounds Using the copper-catalyzed Chan-Lam coupling, we synthesized new N-arylcytisine derivatives at room temperature, in air and using inexpensive phenylboronic acids. Cytisine and 3,5-dihalocytisines can act as substrates, and among the products, the p-Br-derivative was used as a substrate to obtain biaryl derivatives under Pd-coupling conditions; ester-derivative was converted into its acid and amide derivatives using classical carbodiimide conditions. This shows that the Chan-Lam cross-coupling reaction can be included as a versatile synthetic tool in the derivatization of natural products.(3-Fluorophenyl)boronic acid(cas: 768-35-4Computed Properties of C6H6BFO2) was used in this study.
(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Computed Properties of C6H6BFO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics