In 2019,Journal of Heterocyclic Chemistry included an article by Sawkmie, Micky Lanster; Paul, Dipankar; Kalita, Gitumoni; Agarwala, Khushboo; Maji, Pradip K.; Chatterjee, Paresh Nath. Related Products of 622-95-7. The article was titled 《Synthesis and characterization of active cuprous oxide particles and their catalytic application in 1,2,3-triazole synthesis via alkyne-azide cycloaddition reaction in water》. The information in the text is summarized as follows:
Active cuprous oxide materials were synthesized from CuSO4.5H2O using sodium stannite as reducing agent in the presence of various stabilizers, viz., cetyl tri-Me ammonium bromide, sodium dodecyl sulfate and polyvinyl pyrrolidone. The synthesized cuprous oxide materials were well characterized by powder X-ray diffraction and Fourier transform IR spectroscopy to ascertain their identity, while field emission SEM and energy-dispersive spectroscopy anal. were used to study their morphol. and composition, resp. The various cuprous oxide materials were used in the cycloaddition reaction of alkynes, benzyl halides and azides to synthesize 1,4-disubstituted-1,2,3-triazoles I [R = allyl, Bn, 3-ClC6H4CH2, etc.; R1 = CH2OH, Ph, 4-MeC6H4, 4-FC6H4, 4-BrC6H4, 2-pyridyl]. A wide variety of substitutions could nicely be tolerated in our optimized reaction conditions to produce very good to excellent yields of the corresponding triazoles in water at 55 °C. The reactions were carried out in water without any assistance of organic cosolvent or other additives, which renders the catalytic method as economical and environment friendly. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Related Products of 622-95-7)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Related Products of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics