Schell, Peter; Richards, Matthew P.; Hanson, Kelley; Berk, Scott C.; Makara, Gergely M. published an article on February 28 ,2005. The article was titled 《Versatile Solid-Phase Synthesis of Trisubstituted 1H-Pyrido[2,3-d]pyrimidin-4-ones and Related Heterocycles》, and you may find the article in Journal of Combinatorial Chemistry.COA of Formula: C7H8Cl2FN The information in the text is summarized as follows:
A solid-phase synthesis of trisubstituted 1H-pyrido[2,3-d]pyrimidin-4-ones I [R1 = n-Pr, MeOCH2CH2, cyclohexyl, 4-MeC6H4CH2, 2-(morpholino)ethyl; R2 = n-Pr, 4-FC6H4CH2, PhOCH2CH2, 2-(3-pyridyl)ethyl, etc.; R3R4N = morpholinyl, Me2N, Me2NCH2CH2NMe, Et2NCH2CH2NH, etc.] has been developed. The synthesis utilizes solid-phase bound N-2,6-dichloronicotinoyl-1H-benzotriazole-1-carboximidamides as key intermediates. Sequential substitution of benzotriazole moiety and the two chlorine atoms furnishes I regioselectively with high purity. Application of the method to various disubstituted analogs is also demonstrated. The experimental part of the paper was very detailed, including the reaction process of (4-Chloro-2-fluorophenyl)methanamine hydrochloride(cas: 202982-63-6COA of Formula: C7H8Cl2FN)
(4-Chloro-2-fluorophenyl)methanamine hydrochloride(cas: 202982-63-6) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.COA of Formula: C7H8Cl2FN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics