Shang, Jia-Qi; Fu, Hong; Li, Yi; Yang, Tao; Gao, Chuanzhu; Li, Ya-Min published the artcile< Copper-catalyzed decarboxylation/cycloaddition cascade of alkynyl carboxylic acids with azide>, Safety of 3-(4-Chlorophenyl)propiolic acid, the main research area is copper catalyzed decarboxylation cycloaddition cascade alkynoic acid azide; triazole synthesis decarboxylation cycloaddition cascade alkynoic acid azide.
A copper-catalyzed decarboxylation/cycloaddition cascade of alkynyl carboxylic acids with azide has been developed [e.g., phenylpropiolic acid + (azidomethyl)trimethylsilane → 4-phenyl-1-[(trimethylsilyl)methyl]-1H-1,2,3-triazole (97%) in presence of Cu2O in MeCN]. This reaction exhibits good functional group tolerance and wide substrate scope, provides an efficient way to construct 1,4-disubstituted 1,2,3-triazoles.
Tetrahedron published new progress about 1,3-Dipolar cycloaddition reaction. 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Safety of 3-(4-Chlorophenyl)propiolic acid.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics