Synthetic Route of C43H72Cl2P2RuIn 2020 ,《Stereoselective Synthesis of Tetrahydroisoquinolines from Chiral 4-Azaocta-1,7-diynes and 4-Azaocta-1,7-enynes》 was published in European Journal of Organic Chemistry. The article was written by Sirvent, Ana; Garcia-Munoz, M. Jesus; Yus, Miguel; Foubelo, Francisco. The article contains the following contents:
The N-propargylation of enantioenriched homopropargylic amine derivatives III (R1 = e.g., phenethyl) proceeds in high yields under basic conditions. The resulting 4-azaocta-1,7-dynes V were transformed into 1,2,3,4-tetrahydrosioquinolines VII (R2 = e.g., Et) bearing substituents at 3-, 6- and 7-positions, upon reaction with sym. alkynes, through a [2+2+2] cyclotrimerization promoted by Wilkinson catalyst. Ruthenium-catalyzed ring closing metathesis of azaocta-1,7-enynes (e.g., IX) gave 1,3-diene X in high yields. Tetrahydroisoquinoline XII with a substitution pattern in the aromatic ring different from VII was prepared by a [4+2] cycloaddition of di-Me acetylenedicarboxylate with diene X. Other substitution patters were also obtained. In the experiment, the researchers used Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Synthetic Route of C43H72Cl2P2Ru)
Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Synthetic Route of C43H72Cl2P2Ru
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics