The author of 《Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication》 were Skerlj, Renato; Bridger, Gary; Zhou, Yuanxi; Bourque, Elyse; McEachern, Ernest; Langille, Jonathan; Harwig, Curtis; Veale, Duane; Yang, Wen; Li, Tongshong; Zhu, Yongbao; Bey, Michael; Baird, Ian; Sartori, Michael; Metz, Markus; Mosi, Renee; Nelson, Kim; Bodart, Veronique; Wong, Rebecca; Fricker, Simon; MacFarland, Ron; Huskens, Dana; Schols, Dominique. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2011. Reference of Ethyl 6-chloro-2,4-dimethylnicotinate The author mentioned the following in the article:
A series of CCR5 antagonists, e.g. I, were optimized for potent inhibition of R5 HIV-1 replication in peripheral blood mononuclear cells. Compounds that met acceptable ADME criteria, selectivity, human plasma protein binding, potency shift in the presence of α-glycoprotein were evaluated in rat and dog pharmacokinetics. In the experimental materials used by the author, we found Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0Reference of Ethyl 6-chloro-2,4-dimethylnicotinate)
Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Reference of Ethyl 6-chloro-2,4-dimethylnicotinate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics