Taha, Muhammad; Rahim, Fazal; Khan, Aftab Ahmad; Anouar, El Hassane; Ahmed, Naveed; Shah, Syed Adnan Ali; Ibrahim, Mohamed; Zakari, Zainul Amiruddin published the artcile< Synthesis of diindolylmethane (DIM) bearing thiadiazole derivatives as a potent urease inhibitor>, HPLC of Formula: 22952-32-5, the main research area is indolylmethyl phenylthiadiazolyl arenesulfonamide preparation urease inhibition SAR mol docking.
The synthesis of diindolylmethane (DIM) derivatives based-thiadiazole I [R = Ph, 2,4-dichlorophenyl, 1-naphthyl, etc.] as a new class of urease inhibitors. Diindolylmethane-based-thiadiazole analogs I were synthesized and characterized by various spectroscopic techniques 1HNMR, 13C-NMR, EI-MS and evaluated for urease (jack bean urease) inhibitory potential. All compounds I showed excellent to moderate inhibitory potential having IC50 value within the range of 0.50 ± 0.01 to 33.20 ± 1.20μM compared with the standard thiourea (21.60 ± 0.70μM). Compound I [R = 2,4-dinitrophenyl] (IC50 = 0.50 ± 0.01μM) was the most potent inhibitor amongst all derivatives I. Structure-activity relationships have been established for all compounds I. The key binding interactions of most active compounds with enzyme were confirmed through mol. docking studies.
Scientific Reports published new progress about Arenesulfonyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, HPLC of Formula: 22952-32-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics