Reference of Methyl 5-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylateOn June 1, 2008, Teng, Xin; Keys, Heather; Yuan, Junying; Degterev, Alexei; Cuny, Gregory D. published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors》. The article mentions the following:
Necroptosis is a regulated caspase-independent cell death pathway resulting in morphol. reminiscent of passive nonregulated necrosis. Several diverse structure classes of necroptosis inhibitors have been reported to date, including a series of [1,2,3]thiadiazole benzylamide derivatives However, initial evaluation of mouse liver microsome stability indicated that this series of compounds was rapidly degraded. A structure-activity relationship (SAR) study of the [1,2,3]thiadiazole benzylamide series revealed that increased mouse liver microsome stability and increased necroptosis inhibitory activity could be accomplished by replacement of the 4-cyclopropyl-[1,2,3]thiadiazole with a 5-cyano-1-methylpyrrole. In addition, the SAR and the cellular activity profiles, utilizing different cell types and necroptosis-inducing stimuli, of representative [1,2,3]thiadiazole and pyrrole derivatives were very similar suggesting that the two compound series inhibit necroptosis in the same manner. In the experiment, the researchers used many compounds, for example, Methyl 5-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate(cas: 306936-53-8Reference of Methyl 5-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate)
Methyl 5-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate(cas: 306936-53-8) belongs to pyrroles. Pyrroles are components of more complex macrocycles, including the porphyrinogens and products derived therefrom, including porphyrins of heme, the chlorins, bacteriochlorins, and chlorophylls. Porphobilinogen, a trisubstituted pyrrole, is the biosynthetic precursor to many natural products such as heme.Reference of Methyl 5-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics