《Organocatalytic Enantioselective Synthesis of Tetrasubstituted α-Amino Allenoates by Dearomative γ-Addition of 2,3-Disubstituted Indoles to β,γ-Alkynyl-α-imino Esters》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Yang, Junxian; Wang, Zheng; He, Zeyuan; Li, Guofeng; Hong, Liang; Sun, Wangsheng; Wang, Rui. Application In Synthesis of Methyl 2-chloro-2-oxoacetate The article mentions the following:
The first asym. synthesis of tetrasubstituted α-amino allenoates by a chiral phosphoric acid catalyzed dearomative γ-addition reaction of 2,3-disubstituted indoles to β,γ-alkynyl-α-imino esters is reported. This method provides access to a series of highly functionalized tetrasubstituted allenes featuring quaternary stereocenters in high yields, and with excellent regio-, diastereo-, and enantioselectivities under mild conditions without byproduct formation. Representative large-scale reactions and diverse transformations of the products into various scaffolds with potential biol. activities render are also disclosed. The mechanism of the reaction was elucidated by control reactions and DFT calculationsMethyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application In Synthesis of Methyl 2-chloro-2-oxoacetate) was used in this study.
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application In Synthesis of Methyl 2-chloro-2-oxoacetate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics