Yang, Zhimou; Ho, Pak-Leung; Liang, Gaolin; Chow, Kin Hung; Wang, Qigang; Cao, Yang; Guo, Zhihong; Xu, Bing published an article on January 17 ,2007. The article was titled 《Using β-Lactamase to Trigger Supramolecular Hydrogelation》, and you may find the article in Journal of the American Chemical Society.Recommanded Product: (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride The information in the text is summarized as follows:
This paper reports the rational design and synthesis of a β-lactam conjugate. Treating the conjugate with β-lactamase cleaves the scissile β-lactam amide bond, releases a hydrogelator, and results in enzymic formation of a supramol. hydrogel. The process involves the use of a bacterial enzyme-the one causes antibiotic inactivation and accounts for resistance to β-lactams in many clin. important pathogens-to catalyze the formation of the hydrogel. It offers an opportunity to investigate the kinetics of these types of enzymic reactions, screen inhibitors of the enzyme, and provides a new candidate to generate hydrogels for biomedical applications. In the experimental materials used by the author, we found (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Recommanded Product: (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride)
(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics