Zhang, Jin; Zhang, Pei; Shao, Lei; Wang, Ruihong; Ma, Yangmin; Szostak, Michal published an article in 2022. The article was titled 《Mechanochemical Solvent-Free Suzuki-Miyaura Cross-Coupling of Amides via Highly Chemoselective N-C Cleavage》, and you may find the article in Angewandte Chemie, International Edition.Product Details of 768-35-4 The information in the text is summarized as follows:
The first mechanochem. strategy for highly chemoselective, solvent-free palladium-catalyzed cross-coupling of amides by N-C bond activation was reported. The method was conducted in the absence of external heating, for short reaction time and shows excellent chemoselectivity for σ N-C bond activation. The reaction showed excellent functional group tolerance and could be applied to late-stage functionalization of complex APIs and sequential orthogonal cross-couplings exploiting double solventless solid-state methods. The results extend mechanochem. reaction environments to advance the chem. repertoire of N-C bond interconversions to solid-state environmentally friendly mechanochem. methods. The experimental part of the paper was very detailed, including the reaction process of (3-Fluorophenyl)boronic acid(cas: 768-35-4Product Details of 768-35-4)
(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Product Details of 768-35-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics