Zotova, S. A.; Gololobova, T. M.; Stolyarchuk, A. A.; Stepanyuk, G. I.; Bobruk, V. P.; Ivanova, N. I.; Mostovaya, N. I. published an article on January 31 ,1988. The article was titled 《Synthesis and pharmacological activity of 2-aryl-3-carbethoxy-5-oxybenzofuran derivatives》, and you may find the article in Khimiko-Farmatsevticheskii Zhurnal.Electric Literature of C8H6Cl2O3 The information in the text is summarized as follows:
A series of 9 title derivatives (I, R1 = H, OMe, Br, Cl, I; R2 = H, CH2NMe2; R3 = H, OMe, Br, Cl, I) was prepared by condensation of substituted 5-methoxybenzoylacetic Et esters with p-benzoquinone and subsequent reaction with Me2NH. Acute toxicity and cardiotropic and neurotropic effects of I were tested in mice and isolated rabbit intestine. I had a hypotonic effect on intestinal smooth muscles and some increased coronary circulation. However, their activities were inferior to those of the related known drugs fenikaberan and cordarone. After reading the article, we found that the author used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Electric Literature of C8H6Cl2O3)
3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Electric Literature of C8H6Cl2O3 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics