Kondo, Takashi; Nekado, Takahiro; Sugimoto, Isamu; Ochi, Kenya; Takai, Shigeyuki; Kinoshita, Atsushi; Hatayama, Akira; Yamamoto, Susumu; Kishikawa, Katsuya; Nakai, Hisao; Toda, Masaaki published an article on February 15 ,2008. The article was titled 《Design and synthesis of DPP-IV inhibitors lacking the electrophilic nitrile group》, and you may find the article in Bioorganic & Medicinal Chemistry.Application In Synthesis of 5-Chloro-1,2,4-thiadiazole The information in the text is summarized as follows:
A series of (4β-substituted)-L-prolylpyrrolidine analogs lacking the electrophilic nitrile function were synthesized and their dipeptidyl peptidase IV (DPP-IV) inhibitory activity and duration of ex vivo activity were evaluated. Structural optimization of the analog (I), which was found by high-speed analog synthesis, was carried out to improve the potency and duration of action. A representative compound (II) was evaluated to assess its effect on the plasma glucose level after the oGTT (oral glucose tolerance test) in normal rats. Structure-activity relationships (SAR) are also presented. The results came from multiple reactions, including the reaction of 5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Application In Synthesis of 5-Chloro-1,2,4-thiadiazole)
5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 5-Chloro-1,2,4-thiadiazole
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics