The author of 《Design, synthesis, and structure-activity relationship studies of L-amino alcohol derivatives as broad-spectrum antifungal agents》 were Zhao, Liyu; Tian, Linfeng; Sun, Nannan; Sun, Yin; Chen, Yixuan; Wang, Xinran; Zhao, Shizhen; Su, Xin; Zhao, Dongmei; Cheng, Maosheng. And the article was published in European Journal of Medicinal Chemistry in 2019. Related Products of 768-35-4 The author mentioned the following in the article:
To discover broad spectrum antifungal agents, two strategies were applied, and a novel class of L-amino alc. derivatives were designed and synthesized. 3-F substituted compounds 14i(A), 14n(B), 14s(C) and 14v(D) exhibited excellent antifungal activities with broad antifungal spectra against C. albicans and C. tropicalis, with MIC values in the range of 0.03-0.06 μg/mL, and against A. fumigatus and C. neoformans, with MIC values in the range of 1-2 μg/mL. Notably, Compounds A, B, C and D also displayed moderate activities against fluconazole-resistance strains 17# and CaR that were isolated from AIDS patients. Moreover, only compounds in the S-configuration showed antifungal activity. Preliminary mechanistic studies showed that the potent antifungal activity of D stemmed from inhibition of C. albicans CYP51. Compounds B and D were almost nontoxic to mammalian A549 cells, and their stability in human plasma was excellent.(3-Fluorophenyl)boronic acid(cas: 768-35-4Related Products of 768-35-4) was used in this study.
(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Related Products of 768-35-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics