Armstrong, Tom; Lamont, Malcolm; Lanne, Alice; Alderwick, Luke J.; Thomas, Neil R. published the artcile< Inhibition of Mycobacterium tuberculosis InhA: Design, synthesis and evaluation of new di-triclosan derivatives>, COA of Formula: C7H7ClO2, the main research area is triclosan triazole preparation regioselective InhA inhibitor docking; InhA; Isoniazid; Mycobacterium tuberculosis; TB; Triazole; Triclosan.
A library of new 1,5-triazoles I [R = H, Me, pyrrolidin-1-yl, etc.], designed to mimic the structures of both triclosan mols. uniquely bound to InhA was synthesized. The inhibitory activity of these compounds was evaluated using isolated enzyme assays with I [R = 4-chloro-2-hydroxyphenoxy] exhibiting an IC50 of 5.6μM. Whole-cell evaluation was also performed, with I [R = cyclopropylmethoxy] showing the greatest potency, with an MIC99 of 12.9μM against M. bovis.
Bioorganic & Medicinal Chemistry published new progress about Alkynes, aryl Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, COA of Formula: C7H7ClO2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics