Blake, Steven; Thanissery, Rajani; Rivera, Alissa J.; Hixon, Mark S.; Lin, Mingliang; Theriot, Casey M.; Janda, Kim D. published an article in Journal of Medicinal Chemistry. The title of the article was 《Salicylanilide Analog Minimizes Relapse of Clostridioides difficile Infection in Mice》.Product Details of 350-30-1 The author mentioned the following in the article:
Clostridioides difficile infection (CDI) causes serious and sometimes fatal symptoms like diarrhea and pseudomembranous colitis. Although antibiotics for CDI exist, they are either expensive or cause recurrence of the infection due to their altering the colonic microbiota, which is necessary to suppress the infection. Here, we leverage a class of known membrane-targeting compounds that we previously showed to have broad inhibitory activity across multiple Clostridioides difficile strains while preserving the microbiome to develop an efficacious agent. A new series of salicylanilides was synthesized, and the most potent analog was selected through an in vitro inhibitory assay to evaluate its pharmacokinetic parameters and potency in a CDI mouse model. The results revealed reduced recurrence of CDI and diminished disturbance of the microbiota in mice compared to standard-of-care vancomycin, thus paving the way for novel therapy that can potentially target the cell membrane of C. difficile to minimize relapse in the recovering patient. After reading the article, we found that the author used 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Product Details of 350-30-1)
3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Product Details of 350-30-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics