Danner, Paulami; Bauer, Matthias; Phukan, Prodeep; Maier, Martin E. published the artcile< Total synthesis of cryptophycin 3>, COA of Formula: C8H8BrClO, the main research area is cyclodepsipeptide peptidomimetic cryptophycin analog total synthesis; glycine derivative stereoselective alkylation phenylalanine subunit preparation; oxidation Witting reaction hydroxy ester preparation seco acid esterification; peptide coupling Fmoc protection macrolactamization.
The depsipeptide cryptophycin 3 and the cryptophycin analog [I (R1 = Cl, R2 = OMe; R1 = R2 = H)] were prepared from the corresponding four subunits using Fmoc (Fmoc = 9-fluorenylmethyloxycarbonyl) protecting group for the amino functions. The phenylalanine derivative for cryptophycin 3 [subunit B (II)] was prepared by stereoselective alkylation of glycine derivative The tripeptide analogs, which contains fragments D and C was acquired from the starting amino ester III. After extension at the carboxyl function by esterification with the hydroxy ester III, the seco compounds IV (R1 = Cl, R2 = OMe; R1 = R2 = H) were deprotected and submitted to ring closure by macrolactamization in the presence of TBTU as condensing agent.
European Journal of Organic Chemistry published new progress about (Fluorenylmethoxy)carbonyl group. 320407-92-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrClO, COA of Formula: C8H8BrClO.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics