The author of 《Novel Furochromone Derivatives: Synthesis and Anticancer Activity Studies》 were Demir, Senem; Oezen, Cigdem; Ceylan-Uenluesoy, Meltem; Oeztuerk, Mehmet; Bozdag-Duendar, Oya. And the article was published in Journal of Heterocyclic Chemistry in 2019. Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene The author mentioned the following in the article:
In this study, khellin having furochromone structure, which was obtained from a well-known traditional medicinal plant, was selected. A series of furochromonyl compounds I (X = O, S; R = H, CH3, CH2C(O)OC2H5, 4-FC6H4CH2, 4-H3COC6H4C(O)CH2, etc.) was synthesized for their anticancer activities. Furochromonyl compounds I were synthesized by Knoevenagel reaction of substituted 2,4-thiazolidinediones/rhodanines II with khellin-2-carboxaldehyde, and their cytotoxicity was investigated in 22 cancer cell lines, which were originated from tissues such as liver, breast, colon, and cervix. As the first step, two hepatocellular carcinoma cell lines Huh7 and PLC/PRF/5 (Alexander cells) were treated with 10 μM of each compound for 72 h, and then sulforhodamine B assay was performed to analyze their anti-growth activities. Compound I (X = S; R = CH2C(O)OC2H5) was found as the most cytotoxic compound of primary screening. Afterwards, 12 hepatocellular carcinoma, seven breast cancer, two colon cancer, and cervical cancer cell lines were selected to test I (X = S; R = CH2C(O)OC2H5) for 72 h at multiple concentrations to determine 50% EDs. Results showed that 14 cell lines were affected by I (X = S; R = CH2C(O)OC2H5) quantities lower than 10 μM. The structure of I (X = S; R = CH2C(O)OC2H5), which is particularly effective on breast cancers, can be used to slow down the progression of tumors. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics