El-Zahraa, F.; El-Basil, S.; El-Sayed, M.; Ghoneim, K. M.; Khalifa, M. published the artcile< Synthesis and pharmacological screening of certain N-substituted amides structurally related to some local anesthetics>, Product Details of C7H8ClN, the main research area is anesthesia pivalamide diphenylacetamide; pivalamide preparation anesthetic; diphenylacetamide preparation anesthetic.
Eighteen Ph2CHCONHR (I; R = e.g., 2,6-, 2,5-, 2,4-, 3,4-, 3,5-Me2C6H3, 4,5-MeClC6H3, 4-O2NC6H4) and 14 Me3CCONHR1 (II; R1 = e.g., 3,6-Me2C6H3, 3-pyridyl, 4-nitro-2-pyridyl) were prepared in 45-90% yield by reaction of the acid chloride with the resp. amine. The most active intradermal anesthesia in guinea pigs was I (R = 4-methyl-5-chlorophenyl); its activity was more than double that of procaine hydrochloride. As a corneal anesthetic II (R1 = 2,6-Me2C6H3) was the most active anesthetic and for plexus anesthesia I (R = 2,6-Me2C6H3) was the most active.
Pharmazie published new progress about Anesthetics. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Product Details of C7H8ClN.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics