Ellison, Corie A.; Tankersley, Kevin O.; Obringer, Cindy M.; Carr, Greg J.; Manwaring, John; Rothe, Helga; Duplan, Helene; Genies, Camille; Gregoire, Sebastien; Hewitt, Nicola J.; Jamin, Carine Jacques; Klaric, Martina; Lange, Daniela; Rolaki, Alexandra; Schepky, Andreas published the artcile< Partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids>, Computed Properties of 6055-19-2, the main research area is partition coefficient diffusion human intact skin; Diffusion coefficient; Infinite dose; Partition coefficient; Skin absorption; Skin penetration.
A standard protocol was used to determine partition (K) and diffusion (D) coefficients in dermatomed human skin and isolated human skin layers for 50 compounds relevant to cosmetics ingredients. K values were measured in dermatomed skin, isolated dermis, whole epidermis, intact stratum corneum (SC), delipidized SC and SC lipids by direct measurements of the radioactivity in the tissue layers/lipid component vs. buffer samples. D determinations were made in dermatomed skin, isolated dermis, whole epidermis and intact SC using a non-linear regression of the cumulative receptor fluid content of radiolabeled compound, fit to the solution of Fick’s 2nd Law. Correlation anal. was completed between K, D, and physicochem. properties. The amount of interindividual (donor) and intraindividual (replicate) variability in the K and D data was characterized for each skin layer and chem. These data can be further used to help inform the factors that influence skin bioavailability and to help improve in silico models of dermal penetration.
Toxicology In Vitro published new progress about Bioavailability. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Computed Properties of 6055-19-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics