《Rates of alkaline hydrolysis of meta-and para-substituted ethyl β-phenylpropionates and correlation with σ0》 was published in Journal of Organic Chemistry in 1966. These research results belong to Fuchs, Richard; Caputo, Joseph A.. Product Details of 7116-36-1 The article mentions the following:
A series of 20 meta-and para-substituted Et β-phenylpropionates were prepared, and the rates of alk. hydrolysis in 87.8% ethanol at 30° measured. The rates generally follow the σ0 values for the substituents estimated from other reactivities and from F19 N.M.R. shielding in similar solvents. The unexpectedly high rate of the m-Me3N+ compound may be due to a direct, short-range electrostatic interaction in the transition state for hydroxide ion attack of the ester. The results came from multiple reactions, including the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Product Details of 7116-36-1)
Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Product Details of 7116-36-1 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics