Gasonoo, Makafui; Thom, Zachary W.; Laulhe, Sebastien published the artcile< Regioselective α-Amination of Ethers Using Stable N-Chloroimides and Lithium tert-Butoxide>, Recommanded Product: 1-Chloropyrrolidine-2,5-dione, the main research area is chloroimide ether amination lithium butoxide; hemiaminal ether regioselective preparation; lithium butoxide amination mediator.
Herein it is described a metal-free regioselective α-amination of ethers mediated by N-chloroimides in ethereal solvents in the presence of lithium tert-butoxide. This reactivity of N-chloroimides leads to the synthesis of hemiaminal ethers in good to excellent yields at room temperature This C-H functionalization is achieved without the use of a light, heat source, or external radical initiators. Initial mechanistic work indicates that the reaction proceeds through a radical pathway.
Journal of Organic Chemistry published new progress about Amination. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Recommanded Product: 1-Chloropyrrolidine-2,5-dione.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics