Gillespie, Roger J.; Bamford, Samantha J.; Gaur, Suneel; Jordan, Allan M.; Lerpiniere, Joanne; Mansell, Howard L.; Stratton, Gemma C. published the artcile< Antagonists of the human A2A receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides>, Formula: C8H4ClF3O2, the main research area is pyrimidine carboxamide preparation Parkinson disease antiparkinsonian; pyrimidinylamine arylcarboxylic chloride pyrimininylcarboxylic acid amine amidation; human A1 A2A A2B A3 receptor antagonist structure activity.
A novel series of antagonists of the human A2A receptor have been identified and have been shown to display good potency and high degrees of selectivity over other receptor sub-types. Displaying in vivo potency in commonly used disease models and high oral bio-availability, this class of compounds may serve as clin. useful treatments for the relief of the symptoms associated with Parkinson’s disease.
Bioorganic & Medicinal Chemistry Letters published new progress about Adenosine A1 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Formula: C8H4ClF3O2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics