《Stoichiometric Photochemical Carbene Transfer by Bamford-Stevens Reaction》 was written by Jana, Sripati; Li, Fang; Empel, Claire; Verspeek, Dennis; Aseeva, Polina; Koenigs, Rene M.. Formula: C3H3ClO3 And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:
A protocol that takes advantage of the in-situ generation of donor-acceptor diazoalkanes from functionalized tosyl hydrazones by Bamford-Stevens reaction is described. This approach was used in C-H and N-H functionalization and cyclopropanation of nitrogen heterocycles, and the wide scope is illustrated by 51 examples. For example, irradiation of N-tosyl hydrazones RC(CO2Me):NNHTs (R = Ph, 4-MeC6H4, 3-Me-4-MeOC6H4. 4-ClC6H4, etc.) with various R1-substituted N-R2-indoles (R1 = H, 5-Br, 5-MeO2C, 6-F, 4-Br, etc.; R2 = Me, H2C:CHCH2, PhCH2, 4-MeOC6H4, 2-thienyl, etc.) under basic conditions provided the corresponding indoleacetates I in moderate to high yields. Following this strategy, the concentration of the diazoalkane reaction partner was minimized to reduce unwanted side reactions and to now conduct photochem. carbene transfer reactions under stoichiometric reaction conditions. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Formula: C3H3ClO3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Formula: C3H3ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics