Luo, Zhonghua; Sun, Guodong; Wu, Shuming; Chen, Yong; Lin, Yicao; Zhang, Lei; Wang, Zhongqing published an article in 2021. The article was titled 《η6-Arene CH-O Interaction Directed Dynamic Kinetic Resolution-Asymmetric Transfer Hydrogenation (DKR-ATH) of α-Keto/enol-Lactams》, and you may find the article in Advanced Synthesis & Catalysis.Recommanded Product: Methyl 2-chloro-2-oxoacetate The information in the text is summarized as follows:
Dynamic kinetic resolution – asym. transfer hydrogenation (DKR-ATH) methodol. for α-keto/enol-lactams, e.g., I (R1 = Me, i-Pr, n-Bu, PhCH2, 4-MeOC6H4; R2 = Me, MeO2C, PhCH2, 2-thienylmethyl, etc.), that provided a series of the corresponding chiral hydroxy lactams, e.g., II, has been developed. A possible catalytic mechanism evolving a transition state stabilized by η6-arene CH-O interaction was also proposed. This efficient approach can be applied to a wide range of substrates including non-aryl ones which would be difficult to prepare by other asym. reduction methods. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Recommanded Product: Methyl 2-chloro-2-oxoacetate)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: Methyl 2-chloro-2-oxoacetate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics