Mahato, Chandan K.; Mukherjee, Sayan; Kundu, Mrinalkanti; Vallapure, Virbhadra P.; Pramanik, Animesh published the artcile< Asymmetric 1,4-Michael Addition in Aqueous Medium Using Hydrophobic Chiral Organocatalysts>, Related Products of 5153-70-8, the main research area is proline organocatalyst asym Michael water green solvent.
Organic transformations exclusively in water as an environmentally friendly and safe medium have drawn significant interest in the recent years. Moreover, transition metal-free synthesis of enantiopure mols. in water will have a great deal of attention as the system will mimic the natural enzymic reactions. In this work, a new set of proline-derived hydrophobic organocatalysts have been synthesized and utilized for asym. Michael reactions in water as the sole reaction medium. Among the various catalysts screened, the catalyst 1 is indeed efficient for stereoselective 1,4-conjugated Michael additions (dr: >97:3, ee up to >99.9%) resulting in high chem. yields (up to 95%) in a very short reaction time (1 h) at room temperature This methodol. provides a robust, green, and convenient protocol and can thus be an important addition to the arsenal of the asym. Michael addition reaction. Upon successful implementation, the present strategy also led to the formation of an optically active octahydroindole, the key component found in many natural products.
Journal of Organic Chemistry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Related Products of 5153-70-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics